Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy.

Interestingly, in the control treatment group a borderline significant increases of BP values were observed, leading to the difference in change of SBP of 11.1 mmHg (95% CI 6.5–15.8) and DBP of 8.3 mmHg (95% CI 3.98–12.6) between CPT and IPT groups ( Figure 2 A and B ).

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Median-based and inverse-variance weighted approaches detected nominally significant causal association between periodontitis-linked SNPs and SBP or PP ( Table 1 ).

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