Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility.

Moreover, a significant trend (p = 0.003) in fluconazole use during the whole time period considered emerged, particularly in the ICU (p = 0.017), but also in the general medicine wards (p = 0.03).

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In general, apart from anidulafungin and itraconazole, an increasing trend of drug consumption was observed consistent with the above-mentioned significant enhanced trend of Candida BSIs.

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