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Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits.

BMC Pulm Med · 2019 · PMC6839173 · PMID 31699064

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showed a trendno p-value reported
Moreover, the brain structures of the abovementioned groups of COPD patients showed a trend of progressive change.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.