nearly significantp = 0.0513
When compared to age-matched SIRT brain-specific OE and LM mice, SIRT1 brain-specific KO animals at 45 weeks of age exhibited a significantly lower fat mass ( n = 5-8 mice per group, p < 0.01), while the 65-week-old SIRT1 brain specific KO mice had a nearly significant ( p = 0.0513) reduction in fat mass ( n = 4-10 mice per group).