a strong trendP = 0.055
Notably, ISI was also significantly reduced when cells were clamped at −70 mV (WT: 24.8 ms, KO: 16.5 ms; P = 0.001) and rheobase was reduced as a strong trend (WT: 90 pA, KO: 75 pA; P = 0.055) ( Supplementary Figure 4 and Supplementary Table 4 ), excluding confounding effects that our reported difference in resting membrane potential could cause.