Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation.

Wnt1 directly suppresses osteoclastogenesis in a juxtacrine manner Because we did observe increased osteoclast number and eroded surface in Wnt1 Prrx1 –/– mice at 12 weeks, we next asked how does Wnt1 regulate osteoclast differentiation? There was no osteoclast phenotype in Wnt1 +/– mice in vivo, and although parathyroid hormone (PTH) treatment of total bone marrow from Wnt1 +/– mice showed a trend towards increased osteoclastogenesis, co‐culture experiments of control and Wnt1 +/– calvarial cells mixed with control and Wnt1 +/– hematopoietic cells did not indicate any significant osteoclast phenotype in Wnt1 +/– cells in vitro (Supporting Fig. 5A–D).

also in 53,322 other papers