The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.

J Pathol · 2019 · PMC6852434 · PMID 31259422

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Immunohistochemistry revealed that 264RAD treatment of PDAC‐bearing KDC mice significantly reduced tumour cell proliferation (Ki67), tumour growth signalling (pErk), blood vessel density (endomucin), and TGFβ signalling (nuclear Smad4), and showed a trend towards reduced phosphorylated Smad3, αSMA, and collagen deposition (Figure 5 C,D).

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