IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.

Why do the authors artificially define the significance as above 2-fold or below 0.5-fold, and not depend on the statistical analysis in their experiments? It seems that H3K4me3 modification on ORF73 promoter after IFI16 knock-down is quite significant (Figure 1C).

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