Relationship Status between Vancomycin Loading Dose and Treatment Failure in Patients with MRSA Bacteremia: It's Complicated.

Furthermore, when all obese patients were removed from the cohort, the magnitude of the adjusted odds ratios in the multivariate models for loading dose [aOR 0.697 (0.406–1.196)] and first dose ≥ 1750 mg [aOR 0.561 (0.287–1.094)] and treatment failure were similar to that of the overall cohort, and only failed to reach significance for first dose ≥ 1750 mg due to wider confidence intervals due to the decrease in sample size.

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It is noteworthy, however, that, when controlling for other factors, there was a signal between a mg/kg-based first dose and improved outcome that failed to reach statistical significance.

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