a clear trendP < 2.2 × 10 −16
Although circRNA expression shows a clear trend for both positive (β = 1.121, P < 2.2 × 10 −16 ) and negative (β = −1.015, P < 2.2 × 10 −16 ) β values (effect size), there is no such trend in the mRNA expression (β = 0.0294, P = 0.8654; and β = −0.0339, P = 0.8639 for positive and negative β values, respectively).