5 An early 2015 meta-analysis including 22 case–control studies and 8 cohort studies reported a relative risk of 1.18 times for dementia after TBI, but this did not reach statistical significance (95% CI 0.97 to 1.39). s2 Oddly, given the greater severity, those who lost consciousness after injury did not show elevated dementia risk in the most recent meta-analysis; this may reflect the relatively smaller number of participants in this subgroup.
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Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia.
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