Diabetic DR3DQ2×RIP-B7.1 mice displayed higher levels of autoantibodies compared with DR4×RIP-B7.1 mice that do not develop diabetes spontaneously but this difference did not reach statistical significance (Fig. 1d, f ).
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Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease.
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