Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.

Int J Mol Sci · 2019 · PMC6862029 · PMID 31731563

Europe PMC DOI

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an overall trendno p-value reported

Both mean and median values decrease from class A to class D (5.72 to 3.4 and 5 to 3, respectively, in HBA; 3.9 to 1.6 and 4 to 1, respectively, in HBD), indicating an overall trend to lose activity with a lower HBD count.

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a clear trendno p-value reported

Nonetheless a clear trend of correlation between activity and similarity is observed.

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