a significant trendP value = 1.91 × 10 −4
The dose and response exhibit a significant trend (at the 0.05 level) for both datasets (one-tailed Cochran-Armitage test 31 , n = 6 and P value = 1.91 × 10 −4 for DS1, n = 11 and P value = 1.11 × 10 −5 for DS2).