Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction.

The improvement of IPSS and IIEF5 scores also correlate with amplitude of MMN wave (r = −0.639; p = 0.04, and r = 0.628; p = 0.05, respectively) and there were almost significant correlations of IPSS with the other electrophysiological parameters (latency: r = 0.546, p = 0.06; and area: r = −0.368, p = 0.06).

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Patients with BPH/LUTS-ED showed a trend to a higher MMN latency (242 ± 7 vs . 228 ± 7 ms for controls) (Fig. 4A ) and a significantly lower amplitude (1.6 ± 0.4 μV) than controls (5.5 ± 1 μV) (p < 0.01) (Fig. 4B ).

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