Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial.

The only borderline significant (treatment effect = 1.2; 95% CI, 0.0-2.4; P = .05) differences seen in these sensitivity analyses were between the groups receiving 400 mg and 200 mg minocycline hydrochloride.

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There was a borderline significant trend toward greater efficacy in younger patients than in older patients, but this unanticipated finding could be a chance occurrence given the number of subgroup investigations.

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