Also in this setting, DDIT3 , HSPA5, HSP90B1 , ATF6 , and XBP1 levels exhibited a highly significant positive correlation with CALR expression (Fig. 2 c), corroborating the notion that ovarian cancer cells are subjected to ER stress irrespective of treatment, resulting in spontaneous CALR upregulation in a majority of patients.
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Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients.
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The sentences
A similar trend that failed to reach statistical significance was documented for MT samples (Additional file 1 : Figure S8A).