Barely Significant
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Extent and predictors of grade upgrading and downgrading in an Australian cohort according to the new prostate cancer grade groupings.

Asian J Urol · 2019 · PMC6872773 · PMID 31768317

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a clear trendno p-value reported
Median PSA concentrations at diagnosis also varied across grade groups but a clear trend was not evident.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.