Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice.

The linear regression of PS101 dose on overall survival indicated a slope of 1.46 days/ml/kg of PS101 with a highly significant correlation (95% CI = 0.90 to 2.02, R 2 = 0.90, p = 0.005) in addition to the 34 days of survival when treated with irinotecan alone ( Figure 5A ).

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At 1.03 ml/kg PS101, the mean tumour volume was 6.1-fold smaller than the irinotecan-alone group at day 27 but the difference was barely significant (p = 0.050).

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Here, a clear trend can be seen that increasing the PS101 dose resulted in an extended period of tumour inhibition post treatment that monotonically increased with PS101 dose.

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