Heart insufficiency after combination of verapamil and metoprolol: A fatal case report and literature review.

11 , 25 , 26 , 27 McCourty et al investigated the effect of verapamil on the pharmacokinetics and pharmacodynamics of propranolol in six patients and found an increase in the area under the curve (AUC) of propranolol, that however, did not reach statistical significance. 11 The six patients received the same doses, but AUC of propranolol differed statistically significantly between the subjects.

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