BMI, irAE, and gene expression signatures associate with resistance to immune-checkpoint inhibition and outcomes in renal cell carcinoma.

J Transl Med · 2019 · PMC6878694 · PMID 31767020

Europe PMC DOI

hedged sentences

0.0340

closest p · 0.7× alpha

0.0700

boldest claim

The sentences

marginally significantp = 0.034actually significant

Race showed marginally significant differences for Tinfl ( p = 0.034, two-sided Student’s t -test) and Angio ( p = 0.069) expression with medium effect size [ 41 , 42 ] (Cohen’s d = 0.50 for both signatures).

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did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

There was a trend towards improved OS in obese patients, but this did not reach statistical significance (p = 0.07), perhaps due to small sample size.

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