Indeed, following a strong tendency towards statistical significance, patients harbouring tumours with the E-cad loss /S100P ret molecular phenotype exhibited the worst survival of the cohort ( p = 0.055; Fig. 4 d).
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S100P is a molecular determinant of E-cadherin function in gastric cancer.
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Supporting the relevance of our data, patients displaying the E-cad + /S100P − molecular phenotype had a lower disease-free survival rate than E-cad + /S100P + patients (59% versus 65% of patients, respectively), although these results did not reach statistical significance (Additional file 6 : Figure S4b).