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Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.

BMC Biol · 2019 · PMC6880508 · PMID 31771567

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Moreover, compared with those in Ctsl +/+ mice, brain serotonin levels were also increased in Ctsl −/− mice, although the increase did not reach statistical significance between the two groups (Additional file 14 : Figure S10F).

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