Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability.

The ileal tissue from Nef animals showed a trend of increased levels of ion transport starting at 0.1 mM acetylcholine that reached significance at 10 mM ( Fig 5A ), showing that Nef-treated rats had increased ileal secretion.

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