miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1.

Biomed Res Int · 2019 · PMC6881584 · PMID 31828111

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0540

boldest claim

The sentences

highly significantp < 0.01actually significant

As shown for PC3 cells by Caspase 3/7 assays ( Figure 1(e) ), TRAIL administration compared to control strengthened relative apoptosis in a highly significant manner (188.6 ± 34.4%, p < 0.01).

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showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

Whereas miR-221 overexpressing LNCaP cells showed a trend towards higher cell viability ( p = 0.054), the comparison between TRAIL-treated LNCaP cells after pre-miR-221 or control transfections was statistically significant (119.5 ± 19.7% vs. 84.8 ± 5.6%, p = 0.013).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.