Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.

Despite the higher Ca deposition found in the CKD group, there were minor changes in median aortic mRNA levels of osteogenic differentiation markers (reductions in α-actin and increases in Runx2 and Osterix) compared to the CKD + Bßglucans group, which did not reach statistical significance (Table 4 ).

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