Usefulness and reliability of cell free fetal DNA screening for main trisomies in case of atypical profile on first trimester maternal serum screening.

J Transl Med · 2019 · PMC6883576 · PMID 31779618

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did not reach statistical significanceno p-value reported

In the subgroup analysis, there was a trend of correlation between PE and the subgroup of low levels for both PAPP-A and HCG, compared to the group of both elevated levels or mixed, but it did not reach statistical significance (Fig. 3 ).

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