Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity.

However, when we examined the phenotypic profile of the expanded cells we found that those cultured in HPL showed a trend towards increased CD4 + T cell numbers (Additional file 2 : Figure S1b) as well as a significantly higher percentage of CCR7 + cells representing naïve-like (T N ) and central memory T cells (T CM ) in both CD8 + and CD4 + T cell fractions, independent of CAR construct (Fig. 1 c and d).

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