Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1.

The level of FSH showed a trend toward a time-dependent decrease in stimuli compared to normal levels (Fig. 2 e). fMSCs decreased oxidative damage, increased oxidative protection, improved antiapoptotic effects, and inhibited apoptosis in POI hGCs Given that oxidative stress is an inducer of pathological ovarian aging [ 32 ], we speculated that the fMSC-mediated improvement in ovarian activity might be attributed to the decreased ROS level.

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