Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

In addition, we used quantitative real‐time PCR to detect cytokine changes in temporal lobe cortical and hippocampal tissues; we found that although TNF‐α and IL‐6 mRNA levels were increased in temporal lobe tissues, the difference did not reach statistical significance and that the mRNA expression of iNOS and IL‐1β was not changed 3 days after SE seizures.

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The expression of IL‐10 and Ym1 in temporal lobe and hippocampal tissues of SE mice was not significantly changed, but higher than no‐SE mice in hippocampal tissues (Figure S2G ), while IL‐10 and Ym1 mRNA expression has an increasing trend in the temporal lobes and hippocampal tissues of SE mice which was suppressed by rosiglitazone‐treatment (Figure 5 C,D,G,H). 3.5 SE induced an increase in iNOS expression in microglia but not in rosiglitazone‐treated SE brains Next, we further examined proinflammatory iNOS expression in microglia using immunofluorescence staining in SE mice.

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