Fluctuating renal function and the risk of incident atrial fibrillation: a nationwide population-based study.

Among the subgroups by eGFR trends, subjects with a decreased eGFR trend had a significantly higher risk of AF in those with the highest eGFR variability (Q4), whereas those with maintained eGFR or increased eGFR trends showed a trend for increased risk of AF in those with the highest eGFR variability (Q4).

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For the subgroups of age strata, an increasing trend for developing AF risk was observed in older subjects (adjusted HR 1.030, 95% CI 0.919–1.155 for 20–39 years; adjusted HR 1.078, 95% CI 1.032–1.126 for 40–64 years; and adjusted HR 1.168, 95% CI 1.082–1.260 for ≥65 years, where Q1–3 of each age stratum served as a reference, p-for-interaction = 0.0153).

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On subgroup analyses, Q4 in males or those with a decreasing trend of eGFR had significantly increased risks of incident AF compared to Q1 (HR 1.127, 95% CI 1.082–1.175; and HR 1.115, 95% CI 1.059–1.173, respectively).

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