Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults.

For instance, retinal vasomotor function is, as part of the cerebral circulation, largely dependent on local nitric oxide (NO) production.[ 31 , 32 ] Asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, is a known independent cardiovascular risk factor and has been shown to influence arteriolar and venule diameter.[ 33 ] A comparison of obese and moderately-trained subjects as well as athletes showed a trend to lower ADMA in individuals with higher physical fitness.[ 34 ] This observation may point towards an NO-mediated mechanism for fitness-dependent blood flow measurements in the FAZ area.

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