Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.

Neurosci Lett · 2019 · PMC6892271 · PMID 31422098

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Individual DA neuronal volume was measured and although no treatment effect was seen in cell volume in either strain, A30P mutant α-synuclein overexpressing animals showed a trend towards larger cell volumes than wild type in vehicle and TCE groups and were significantly larger in TaClo treated mice. 5.

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