Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease.

When Li treatment response phenotypes in bipolar patients was screened by a large (1,693 sequence) genome-wide association study of pre-miRNA genes plus 20 kb flanking sequence, only one pre-miRNA gene had a nominally significant (p ≤ 0.05) sequence variation association, but when corrected for multiple comparisons, no polymorphisms in pre-miRNA plus flanking sequence showed any association with Li treatment phenotypes 91 .

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