Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.

To account for the possibility of crosstalk ( 55 , 56 ), a double knockdown of both YAP and MRTF-A did show a significant decrease in SRF transactivation compared with the scramble control, though this decrease did not reach statistical significance with TEAD transactivation ( Fig. 3 C, D ).

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