Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories.

Furthermore, we specifically examined the 91 signature genes significantly associated with iPSCORE iPSC cardiac-fate outcome and found eight with nominally significant expression differences in the same direction (e.g., overexpressed or downregulated) in the two sets of iPSCs ( Figure 5 G), which is 2.5 times more than random expectation (p = 0.012, Fisher's exact test; Figure 5 H).

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We noted that seven borderline significant autosomal genes were also involved in one of the three represented signatures, and therefore added them to the final list of differentially expressed genes.

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