Population Pharmacokinetic Modeling and Exposure-Response Assessment for the Antibody-Drug Conjugate Brentuximab Vedotin in Hodgkin's Lymphoma in the Phase III ECHELON-1 Study.

19 The effect of albumin concentration on clearance was small (~ 3% increase over the range of albumin concentrations—17–53 g/L—in the dataset) but was highly significant ( P < 0.0001) and was thus kept in the model.

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Simulations showed a trend to an increasing MMAE clearance with body size and with increasing CrCl ( Figure 3 d–f , Supplementary Supporting Information and Tables S1 and S2 ).

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