Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.

Although it did not reach statistical significance, MMP activities in the joints of the CII-immunized HLA-DR1 mice treated with Gö6983 were greatly reduced, indicating a possibility that some inflammatory processes in the course of CIA are also mediated through activation of PKC family members, such as PKCα and β, in addition to PKD.

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