a significant trendP =0.004
The mean age of patients at the time of ASR also varied among studies (Table 1 ), with a significant trend towards earlier age at ASR in later decades ( r =0.65, P =0.004, Figure S1 ).
The mean age of patients at the time of ASR also varied among studies (Table 1 ), with a significant trend towards earlier age at ASR in later decades ( r =0.65, P =0.004, Figure S1 ).
9 Annual late mortality was found to be significantly lower for more recent cohorts (Figure 3 A), and for cohorts with a younger mean age at time of ASR (Figure 3 B), which positively correlated with borderline significance.