Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4<sup>+</sup> T Cell Metabolic Rewiring.

SLC5A12 Ab treatment reduced both clinical and histological scores of arthritis as compared to the isotype control and showed a trend effect superior to anti-TNF treatment ( Figures 7 C–7F) Discussion Historically, lactate has been considered a waste product or at best a biomarker in critical care.

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