Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.

Epilepsia · 2019 · PMC6900043 · PMID 31625159

Europe PMC DOI

hedged sentences

0.3760

closest p · 7.5× alpha

0.3760

boldest claim

The sentences

failed to reach statistical significanceP = 0.3760not close (p > 0.1)

CBD and clobazam co‐treatment lowered the proportion (16%) of mice experiencing spontaneous GTCS compared to controls ( P < 0.0001) or clobazam alone (28%), although the latter comparison failed to reach statistical significance ( P = 0.3760).

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highly significantno p-value reported

This was despite the lower dose causing a highly significant pharmacokinetic interaction, increasing clobazam concentrations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.