The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population.

Transl Psychiatry · 2019 · PMC6901563 · PMID 31819045

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0310

boldest claim

The sentences

nominally significantp < 5.00 × 10 −8actually significant

We considered SNPs with a one-tailed p < 0.05 in our primary sample to be nominally significant; in the overall meta-analysis, SNPs with a two-tailed p < 5.00 × 10 −8 was considered genome-wide statistically significant.

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marginally significantp = 0.031actually significant

Notably, the putative MDD risk allele (A) of rs12415800 showed a marginally significant overrepresentation in cases compared with controls (one-tailed p = 0.031, OR = 1.085, Table 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.