Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis.

We first assessed the CSF concentrations of SPM and proinflammatory eicosanoids, finding that SPM concentrations were significantly reduced in patients that died during the study, whereas proinflammatory mediator concentrations tended to be higher in those who survived, although this did not reach statistical significance ( Fig. 3 A, B and Supplemental Table S5 ).

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