Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders: A Systematic Review and Meta-analysis.

To better understand the association between uncharacteristically low control allele frequencies and large ORs observed in some DRD2 association studies and to characterize an overall, meta-analytically significant association, we grouped the studies as highly significant (OR, 1.64; 95% CI, 1.25-2.14), moderately significant (OR, 1.24; 95% CI, 1.15-1.32), or nonsignificant (OR, 1.09; 95% CI, 0.96-1.23).

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