The Effect of Glutamatergic Modulators on Extracellular Glutamate: How Does this Information Contribute to the Discovery of Novel Antidepressants?

Although this pattern did not reach statistical significance, in terms of glutamatergic activity, it was suggested that these brain regions might respond differently to riluzole treatment. 84 The nonselective action of riluzole on different ion channels 88 , 89 may potentially affect glutamatergic transmission in different ways; for example, by modifying the resting potential of astrocytes.

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