Complete device endothelization has been observed after 90 days in animal models, but this time may be protracted in humans, and interindividual variability may be significant, adding uncertainty regarding the optimal type and duration of the antithrombotic therapy after LAAO.
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Antithrombotic Therapy for Percutaneous Cardiovascular Interventions: From Coronary Artery Disease to Structural Heart Interventions.
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On the contrary, a more recent patient-level meta-analysis including the recent results of the ENTRUST trial, showed a trend (although not significant) towards higher risk for stent thrombosis with dual therapy.