A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model.

In Figure 2A , we observed that the capillary diameter had an increasing trend from the WT6 group (4.67 ± 0.06 μm) to the AD6 group (4.98 ± 0.07 um, p = 0.09) and significantly increased from the WT6 group to the AD6&EX group (5.15 ± 0.08 μm, p = 0.011).

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A decreasing trend of RBC velocity from WT6 (0.87 ± 0.03 mm/s) to AD6 (0.79 ± 0.03 mm/s) was also observed (see Figure 2A ).

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When integrating across depths, the AD6 group showed a trend toward a lower average value (8.16 ± 0.37%) compared to the WT6 group (8.85 ± 0.29%) (see Figure 4C ).

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