Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene.

Acta Neuropathol Commun · 2019 · PMC6916051 · PMID 31843010

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showed a trendno p-value reported

GPX4, known to colocalize with neuromelanin showed a trend towards downregulation, in line with the reduction observed in SNpc of PD patients [ 8 ].

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