Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus.

Front Mol Neurosci · 2019 · PMC6917648 · PMID 31920532

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did not reach statistical significanceno p-value reported

Our EPM results did reveal a nearly 40% reduction in open arm time in WT mice following HFD, suggesting that HFD may not have been completely without effect in this test, but this result did not reach statistical significance by two-way ANOVA.

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