RIP1 was apparently involved in this necrosis, since GSK′963 reduced, by ∼35% ± 16.7%, the numbers of both apoptotic and necrotic cells present in Vero cell cultures treated for 30 min with 10 μg/ml CPE, although those protective effects did not reach statistical significance.
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RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens Enterotoxin.
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